Research project / Public software
DS3dRNA
De novo sequence design for target RNA 3D structures, using structural constraints and higher-order interactions.
DS3dRNA searches for nucleotide sequences compatible with a target three-dimensional scaffold. Its public software connects fixed-backbone design with the ranking of candidate sequences.
The documented workflow combines three-body statistical energies, local thermodynamic screening, optional structural constraints, and sequence sampling. It provides a computational route from a target structure to candidate sequences; biological function and experimental validation remain separate questions.
- 01Target 3D structure
Define a structural scaffold and constraints.
- 02Sequence search
Explore candidates using structural and statistical scoring.
- 03Candidate evaluation
Rank sequences for further computational or experimental study.
Public software, ongoing research
The repository’s citation guide describes the manuscript as “to be published.” A publication entry will be added when a public article or preprint is available.
Repository citation guide ↗